The Buffalo Bills are entering the 2025 NFL season with sky-high expectations, as DraftKings sportsbook has them favored in all 17 regular-season games, a rare feat for any team. As of today, May 16, 2025, the reigning AFC runner-ups are the only squad to open as way-too-early favorites in every contest, a testament to the oddsmakers’ confidence in Josh Allen and Sean McDermott’s squad. The Bills kick off their season on September 7 with a “Sunday Night Football” clash against the Baltimore Ravens at Highmark Stadium, where they’re listed as 1.5-point favorites in a rematch of last year’s thrilling AFC Divisional Round showdown.
Buffalo’s schedule sees them as heavy favorites in several games, particularly over the next six weeks after the opener. They’re favored by 5.5 points or more against the Jets (away), Dolphins (home), Saints (home), Patriots (home), Falcons (away), and Panthers (away). Even in tougher matchups, the Bills hold the edge—2.5 points over the Kansas City Chiefs in Week 9, 3.5 points at the Houston Texans in Week 12, and 1.5 points against the defending Super Bowl champion Philadelphia Eagles in Week 17. In all other games, they’re favored by at least 4.5 points, largely due to home-field advantage in key contests against the Ravens, Chiefs, and Eagles.
This unprecedented betting line reflects Buffalo’s consistency, driven by Josh Allen’s MVP-caliber play, but it’s not without risk. The Bills have a history of playoff heartbreak, reaching the AFC Championship in 2020 and again last year, only to fall to Patrick Mahomes’ Chiefs in the postseason for the fourth time in five years. Despite adding Joey Bosa this offseason to bolster their defense, the AFC is stacked with contenders like the Texans, Bengals, Chargers, and Broncos joining the Chiefs and Ravens as elite threats, making Buffalo’s path to the Super Bowl as challenging as ever.
Oddsmakers may adjust these lines—Buffalo could easily become an underdog if injuries or road struggles emerge—but for now, the Bills are the team to beat in every game. With Allen’s dual-threat prowess (65 career rushing touchdowns and 28 passing scores last season) and a roster built for contention, Buffalo has the tools to live up to the hype. Fans will be watching closely to see if this is the year they finally break through, starting with a statement win over the Ravens in Week 1. Can the Bills defy the odds and run the table? The journey starts soon.
